Pioneering The Preventive Care For T2DM With New Biomarker And New Therapeutics

1. Intestinal alkaline phosphatase (IAP) is the new biomarker for prediction of T2DM.

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2. STAP-Test detects and measures IAP (Patented); predicts the risk of developing T2DM

3. SGt2d is the novel therapeutic for prevention of T2DM (patent pending)

About Us

Stapgen

Stapgen is a pioneering MedTech/Biotech company in preventive care of Type 2 Diabetes founded by two brothers in Boston who came from South Asia overcoming significant challenges and disadvantages to achieve success. Educated at prestigious western universities, one brother is now a world-renowned researcher, and the other a successful dentist. Together, they are driven by a mission to prevent Type 2 Diabetes.

Based in Boston, MA, Stapgen is at the forefront of preventive care for Type 2 Diabetes with its groundbreaking STAP-Test. This patented technology, the STAP-Test, is enabling early diagnosis of incipient diabetes, providing us ample time to take preemptive action to prevent Diabetes.

Meet Our Awesome Team

Dr. Madhu S. Malo, MBBS, PhD

Chief Scientist

Malo, MBBS, PhD. He was an Assistant Professor in Harvard Medical School, and a Postdoc in MIT.

Dr. Biplab K. Malo, DMD

Founder and CEO

Malo, DMD graduated from University of Pennsylvania, School of Dental Medicine in 2000.

Suresh Subbu

Technology Advisor

Suresh Subbu is a highly skilled and experienced technology executive

Mark Norige

Biotech Business Advisor

Mark is the Principal and CEO of Board Forum, a thriving CEO peer advisory firm.

Greg Bauer

Business Communication Advisor

Health Connections- Founder. A veteran of business development, marketing and digital health solutions,

Learning

Diabetes

The Three Main Types of Diabetes

Our Mission

To prevent Type 2 Diabetes,

Our Vision

To see a world without Diabetes.

Our Pioneering Specialty

IAPD

IAPD refers to intestinal alkaline phosphatase deficiency. IAPD causes Type 2 Diabetes.

STAP-Test

It detects and measure intestinal alkaline phosphatase (IAP) in a stool sample. If you have no IAP you will develop Type 2 Diabetes; if you have normal level of IAP, you will not develop Type 2 Diabetes.

IAP

IAP is the most important enzyme in the gut. We have two decades of research information on this enzyme. IAP maintains your gut health.

Early Diagnosis of T2DM

Early diagnosis of T2DM is vital for effective management and prevention of complications.

Incipient Diabetes

Incipient diabetes is the early phase of elevated blood sugar levels before a full diabetes diagnosis.

Discover your IAP level

IAP in the gut is the single most important enzyme related to Type 2 Diabetes. IAP deficiency (IAPD) causes Type 2 Diabetes. Therefore, checking your IAP level is extremely important to intercept and prevent diabetes. Ask your primary care physician during annual check up for a STAP-Test.

Our Pipeline

Pioneering in prevention of Type 2 Diabetes

Our pipeline will focus on the preventions and cure of Type 2 Diabetes, with the breakthrough diagnostics and therapeutics. We also have assets that are focusing on

Colorectal cancer
Coronary artery disease
Dementia

Better Health, Brighter Future

Join Us

Work with globally diverse colleagues who are committed to bringing Better Health to people

Investors

Discover our balanced, diverse portfolio and strategy for sustainable, patient centered

R&D

Fueled by our inherent curiosity, we translate science into highly innovative, life-transforming.

Your Support Means Healthier Futures for Diabetes Patients

Diabetes is a life-changing condition that affects millions of people around the world, often leading to serious health complications. For many patients, managing diabetes requires constant care, medication, and lifestyle adjustments, which can be both physically and financially overwhelming.

Our Areas of Focus

Diabetes

Diabetes management is a critical area of focus in healthcare, given the global rise in cases of both Type 1 and Type 2 diabetes.

Cardio metabolic diseases

Cardio-metabolic diseases represent a cluster of interrelated conditions, including cardiovascular disease, type 2 diabetes, and metabolic disorders such as obesity and hypertension.

Neurodegenerative diseases

Neurodegenerative diseases are a group of disorders characterized by the progressive degeneration of nerve cells (neurons) in the brain and spinal cord.

Our Services

#1
Featured Service

STAP- Test to detect T2DM in advance prior to the rise of blood sugar.

#2
Featured Service

Supplements to prevent T2DM

#3
Featured Service

IAP-Toothpaste to prevent infant dental caries

Two Decades of Research

§Issued patent: Diagnosis and treatment of incipient diabetes. U.S. 10,781,470 USPTO (iss 2020), Inventor: MS Malo

2010

Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota, Malo et el., Gut. 2010 Nov;59(11):1476-84 https://pubmed.ncbi.nlm.nih.gov/20947883/ citations: 256

2013

Intestinal alkaline phosphatase prevents metabolic syndrome in mice, Kaliannan et al. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17): 7003-8 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637741/

2015

A High Level of Intestinal Alkaline Phosphatase Is Protective Against Type 2 Diabetes Mellitus Irrespective of Obesity, Malo, EBioMedicine, 1December 2015, https://pubmed.ncbi.nlm.nih.gov/26844282/ citations: 87

2021

In a 5-year prospective cohort human study, Dr. Malo and his team proved, “IAP deficiency increases the risk of T2DM.” Malo et al., BMJ Open Diabetes Res Care. 2022 Jan:10(1)e002643; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796214/ The American Diabetes Association and the British Medical Journal jointed published the BMJ Open Diabetes Res Care journal article.

Our Gallery

Leadership Award

Dr. Biplab Malo – Outstanding Leadership Award | Health 2.0 Conference | USA Summer 2023

Dr. Biplab Malo, Founder & CEO of STAPGEN LLC, shares his transformative experience of being recognized with Outstanding Leadership Award at the Summer Edition of the Health 2.0 Conference, USA on July 10-12, 2023.

Stapgen

Home

Pioneering The Preventive Care For T2DM With New Biomarker And New Therapeutics

About Us

Stapgen

Meet Our Awesome Team

Learning

Diabetes

The Three Main Types of Diabetes

The Three Main Types of Diabetes

The Three Main Types of Diabetes

The Three Main Types of Diabetes

Our Mission

To prevent Type 2 Diabetes,

Our Vision

To see a world without Diabetes.

Our Pioneering Specialty

IAPD

IAPD refers to intestinal alkaline phosphatase deficiency. IAPD causes Type 2 Diabetes.

STAP-Test

It detects and measure intestinal alkaline phosphatase (IAP) in a stool sample. If you have no IAP you will develop Type 2 Diabetes; if you have normal level of IAP, you will not develop Type 2 Diabetes.

IAP

IAP is the most important enzyme in the gut. We have two decades of research information on this enzyme. IAP maintains your gut health.

Early Diagnosis of T2DM

Early diagnosis of T2DM is vital for effective management and prevention of complications.

Incipient Diabetes

Incipient diabetes is the early phase of elevated blood sugar levels before a full diabetes diagnosis.

Discover your IAP level

Our Pipeline

Pioneering in prevention of Type 2 Diabetes

Better Health, Brighter Future

Your Support Means Healthier Futures for Diabetes Patients

Our Areas of Focus

Our Services

Two Decades of Research

Our Gallery

Leadership Award

Dr. Biplab Malo – Outstanding Leadership Award | Health 2.0 Conference | USA Summer 2023